Circle Pharma is developing a new computational paradigm for macrocycle drug discovery based on rational design and synthetic chemistry. The Company’s technology optimizes designs of intrinsically cell permeable drug-like macrocycles in silico, and then automates their total synthesis to accelerate therapeutic target validation. Circle Pharma is initially focusing internal development on disrupting high-value intracellular protein-protein interactions that are key drivers in cancer. Oral administration of macrocycle drugs can also be enabled with Circle’s computational rational drug design platform.
Learn more: https://circlepharma.com/